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This could be consistent with modest activation of the renin-angiotensin-aldosterone system (RAS) [22],[22].
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Inhibition of lysosomes by chloroquine is consistent with modest increases in the levels of LC3 and p62 (Supplementary Figure 2C).
This would be consistent with the modest increase in sensitivity in the rad54∆ rad8 mutants.
10 More recently, a large RCRR study in the Netherlands reported a figure of 4.1%, 11 which would be consistent with a more modest estimate of 9000 such deaths annually in England.
However, even if all mutations had concordant effects on fitness, the range in presented here (1.06-2.14) could be consistent with anything from modest benefits of sexual selection to females to a greater than two-fold fitness advantage compared to a hypothetical asexual competitor, depending on the mutation rate, so refining estimates for through further study will be critical.
A similar reduction in transverse dispersivity in gravity stable flow, independent of Peclet number, was observed and found to be consistent with observations in the literature for more modest density contrasts.
The relationship between the proliferation of cells and crypt height seems to be consistent with the experimental observation showing that the modest changes in cell proliferation rates can account for the large variation of crypt outputs [ 32].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com