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Prompt treatment to prevent dehydration and failure of vascular support should be considered when administering docetaxel.
To avoid thrombotic complications, monitoring of antithrombin activity and co-administration of antithrombin concentrate should be considered when administering PCCs to patients with severe liver disease [ 5].
Cross-cultural adaptation of the HDQ may be considered when administering the instrument in other countries with varying culture or perceptions related to chronic illness [ 48, 49].
Thus, the effectiveness of these plants in managing SCD is generally dependent on the sex of the HbSS patients, and this should be considered when administering plant extracts for the management of SCD.
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In our preliminary study, there was a favorable correlation between AUC and creatinine clearance (CL), suggesting that renal function should be considered when nedaplatin is administered.
Consequently, renal function should be considered when nedaplatin is administered, in order to reduce severe nedaplatin-induced toxicities as far as possible.
Increased frequency of monitoring should be considered when TPV/r is administered to patients with elevated baseline ALT/AST levels, or active HBV/HCV co-infection, as these patients may be at increased risk for developing further transaminase elevations.
As noted above, the potential low endemic environmental exposure must be considered when evaluating the oral administered dose, highlighting the importance of identifying doses that are a realistic representation of human exposure to these chemicals to aid in the design of future animal experiments.
However, this should only be considered when heparin has not been administered within the previous 100 days to avoid the occurrence of rapid onset HIT.
Activation of the sympathetic system before drug administration and the mechanism of action of any administered drug should be considered when interpreting the ECG recordings and HR measurements of an anaesthetised animal.
We believe that this case brings a word of caution to be considered when cancer immunotherapy is combined or concomitantly administered with hormone therapy, evidencing the delicate interactions established between the immune responses elicited by vaccines, the immune-modulating effect of sex hormones and tumor cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com