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According to the procedure presented, a sampling plan could be considered optimized and complete with 19 sampling stations for this study site (comparatively to 38 sampling stations for the total set obtained by systematic sampling).
Using this algorithm, the question of whether the standard code should be considered optimized for error minimization is addressed: optimized versions of the standard code and random blocked codes are obtained, and it is found that the standard code's cost, and that of its optimized version, can be matched or beaten by optimized versions of many random blocked codes.
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The reasons for considering PPI therapy to be optimized were recorded by physicians (multiple response possible); the 'maximum dose' had been reached in 86% of patients, 46% of patients had tried a different brand with no improvement, improvement by changing PPI was considered unlikely due to symptom pattern in 29% and PPI therapy was considered optimized due to other reasons in 9% of patients.
In this regard, physicians were asked to record the reason why PPI therapy was considered optimized, including 'maximum dose' (physicians were not provided with guidance in terms of what constituted 'maximum' dose), 'tried different brands with no improvement'improvementent by changing PPI unlikely due to symptom pattern' and 'other reason' (multiple responses possible).
In the comparison below, optimized adaptive designs were considered, optimized in the parameters r (and thus determined by r) and α0 with respect to the expected utilities and.
The optimization of subsystems individually does not guarantee an optimum for the overall system, and often various design variables must be considered and optimized simultaneously.
For these double beams, the cross-section stiffness was the first factor which to be considered and optimized and the change of the strain along thickness direction was linear, which was in line with the hypothesis theory of bending plane of materials.
The selection of parameters needs to be considered and optimized according to the actual situation.
For more accurate and consistent results, each of these physical and chemical parameters must be considered and optimized accordingly [34].
Patients who had specific circumstances that precluded the use of the above medication optimization paradigm were able to receive review by a cross-site committee of study psychiatrists to determine whether they should be considered effectively optimized.
Therefore, the implementation of the design should be considered carefully with optimized parameters in actual aero-engine.
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