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These survivors should receive appropriate follow-up and be considered for primary intervention.
Strictly, only patients with a high absolute cardiovascular disease risk (≥20%) and no other comorbidities should be considered for primary prevention treatment.
The knowledge generated from this study will help to define the size of the public health problem of allergy in Ecuador and may identify possible environmental exposures that could be considered for primary prevention public health strategies.
Results Of the 41 250 records screened in this study, 36 679 (89%) patients did not have a history of cardiovascular disease and therefore could be considered for primary preventive treatment.
For patients with contraindications or intolerance for β-blockers and for those who are not compliant or do not respond to treatment, variceal band ligation rather than sclerotherapy may be considered for primary prophylaxis [ 44].
Resection of hepatic and/or pulmonary metastases from colorectal cancer remains the only curative option in stage IV patients, but only 10 20% of patients can be considered for primary resection at the time of diagnosis of metastatic disease.
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The following hypotheses are considered for primary analyses with two-sided type I error (alpha) of 5 %: under the null hypothesis (H0), DDC of the two treatment arms is equal (HR Arm A/ Arm B = 1) while under the alternative hypothesis (H1), DDC of the two treatment arms is different (HR Arm A/ Arm B ≠ 1).
For patients who have more than one primary outcome event during the trial, the time to the first occurrence of the primary outcome event will be considered for the primary analysis.
A two-sided level of significance of 5% will be considered for this primary efficacy analysis.
The most severe complications will be considered for the primary endpoint.
Our recommendations would be that performance-based strength measures should be considered for the primary outcome in this younger cohort.
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be targeted for primary
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