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Public-industry risk sharing could also be considered for phase III trial funding.
If this schedule results in a higher dose intensity and more manageable gastrointestinal side effects, it will be considered for phase II testing.
In this regard, Bonnefoi, Nevins and colleagues [ 26] suggest their signatures can identify patients unlikely to benefit from chemotherapy who should be considered for phase I/II clinical trials using novel agents.
Although the MTD was not reached, our results suggest that continuous dosing with olaparib capsules, at the recommended monotherapy dose of 400 mg bid, combined with PLD (40 mg m−2) could be considered for Phase II trials of longer duration.
Nine patients were treated at 429 mg m−2day−1; three out of nine experienced grade 3 nausea, but 17 out of 22 treatment courses were completed (with the co-administration of prophylactic antiemetics) and this dose level could be considered for phase II testing.
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We calculate the mean and standard deviation of fragment size in the BAM file and allow users to limit the distance between paired reads to be considered for phasing.
"The good news that we're being considered for phase two sounds encouraging on the surface, but It's pretty hard to get excited when you're kept from the crucial engineering, architectural and design phase that we have a lot of expertise in," said Senator Frank H. Murkowski, Republican of Alaska.
It is only fair to point out that Monte Carlo methods have already been considered for phase noise estimation in the past [6, 7].
Between July 2004 and February 2014, 4172 patients were considered for phase 1 trial at the Drug Development Unit.
Doses with >50% probability of showing a placebo-adjusted incidence of <5% for >2 g/dl drop in hemoglobin were considered for phase III evaluation.
Thomas Hudson (Ontario Institute for Cancer Research, Canada) reported on a multi-institutional study applying a multi-gene sequencing panel to help direct patients being considered for phase I and II clinical trials.
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