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Importantly, the Vα6-Jα13 TCR, which we named the OVαβ TCR, responded less well to this antigen (Fig. 1B and data not shown) and, therefore, can be considered a functionally lower affinity TCR.
In the light of our findings, the ECU subsheath can be considered a functionally integral part of the TFCC, providing ulnocarpal stability.
Unfortunately, there is not a consensus as to the exact boundaries of perirhinal cortex in the human and whether the more anterior temporal polar region should be considered a functionally distinct region from the more posterior portion of perirhinal cortex.
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In hMC4R, even a seemingly (biophysically) nondisruptive substitution of V95I leads to a loss of function (Supplemental Table 1); however, in hMC1R the G89V mutation in the corresponding position is considered a functionally neutral polymorphism (56).
Prominent expression of NPY by subplate neurons from 16 postconceptional weeks (PCW) in the human has been previously described (Delalle et al. 1997) and is considered a marker for functionally mature neurons in the subplate (Chun et al. 1987).
Oligodendrocytes were considered an important functionally homogeneous population in the CNS, however these cell's morphologies are diverse [105].
Beyond this role in normal physiology, MUC1 is considered an oncoprotein, as its overexpression can functionally drive malignant transformation in breast epithelium [ 33].
In case that the pair of tissues cannot be considered as a functionally equivalent group, these are false positives and avoiding them can be solved by taking a much higher Bayes factor (e.g. log2 = 10, see Fig. 1B) as a demarcation value.
Ambiguity still remains however, because depending on the exact biological context, members of a family, however defined, can sometimes be considered as functionally interchangeable and thus worthy of a common functional identity.
Despite that the exact site and (probably) the responsible kinase are different, it is tempting to postulate that phosphorylation at the very N-terminus of human and yeast Rpt3 may have similar functions, therefore might be considered as "functionally conserved".
In contrast, a non-essential gene can be considered more functionally dispensable and/or redundant [ 70].
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