If the gains from the proposed intervention were likely to be considerable – for example, if we were asked to support credible, local, non-Islamist ground forces – or if we were acting in this way because it was forced on us, some risk would be worth taking.
The difference in protein quantitative assessment may be considerable; for example, for fibrinogen α-chain in Series #1 and Series #2, a value of about 1 pmol was obtained, while in Series #3, the absolute concentration was ten times lower, evidently due to depletion.
In addition, the impact of changing the discount rates was considerable, for example, the ICER increased by 8-11% when an equal discount rate of 3.5% for costs and health effects was applied and decreased by 16-39% when neither costs nor effects were discounted.
There seems to be considerable agreement, for example, that the definition of what constitutes sexual abuse may be too broad.
However even within this group of seven, there are considerable differences; for example Boling et al [ 15] demonstrate a greater range of results than for example Crossley et al [ 14], despite similar inclusion/exclusion criteria.
Twenty-first-century suburbia is a fresh seam by comparison, and the influence of Sinclair's suburban literature has been considerable (as, for example, in Hilary Mantel's haunting Beyond Black).
There is considerable controversy, for example, over the management of pain in chronic pancreatitis, with some clinicians preferring long-term conservative management, others advocating interventional endoscopies, and still others making a plea for surgical procedures[ 6, 14, 19, 20].
That there would be considerable need for work on, for example, politically exposed persons.
The time taken to scan samples with this strategy is often considerable; for example, a typical midscale resolution X-ray fluorescence mapping data set might be 250 pixels ×250 pixels, with a collection time of 0.2 s per point, with an additional 0.1 s per point required to move the stage and perhaps allow for settling.
However, the delay is still considerable; for example, in 2005-2009, 56% of males and 47% of females aged 20-39 hadelayelay of at least 5 years.
The LaMEVE data show column height increases with magnitude, but there is considerable scatter, with, for example, column heights of 30 km recorded for eruptions ranging from M4-8 (Additional file 1: Figure S6).
