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LipL21 has been reported to be conserved in pathogenic leptospiral strains and this has led to its use in PCR-based identification of Leptospira spp. [ 7].
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Comparative genomics strategy is a useful tool in identifying potential new drug targets, such as putative essential genes and/or those affecting the cell viability that are conserved in pathogenic organisms [ 13- 16].
Hha is conserved in pathogens [53] and also represses the expression of other virulence genes in pathogenic E. coli including episomal Vir adhesion [14] and the locus of enterocyte effacement [15].
This function seemed to be conserved in the pathogenic yeast species C. glabrata.
Choosing drug targets that are likely to be conserved in related, human pathogenic species may benefit both canine and human medicine.
In addition to the recognition of commensal microbiota by neuronal cells, the latter are also able to integrate cues from pathogenic microbes.135 Notably, while the capacity of nociceptor neurons to sense fungal and bacterial products has been mostly established in skin,136,137 this sensing ability is likely to be conserved in mucosal neurons.
Our results strongly suggest that KerV orthologs may be universal virulence determinants since they are conserved in many pathogenic Proteobacteria.
The epitope was conserved in several pathogenic mycobacterial species, but not found in the genome of the saprophytic M. smegmatis.
The data in Figure 5 indicate that the genomic order was conserved in the pathogenic strains, and those closely related to them.
Comparisons with the other sequenced E. coli genomes reveal that the location and sequences of the genes encoding this T2SS are conserved in many pathogenic strains of E. coli (Fig. S15).
This motif is conserved in secreted pathogenic Fusarium proteins and a prime candidate for functional testing.
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