Moreover, this regulatory strategy seems to be conserved in insects and vertebrates [22], [48].
In addition, we searched for orthologous miRNA genes in mammals, a nematode, and other insects and found that most silkworm miRNAs are conserved in insects, whereas only a small number of silkworm miRNAs has orthologs in mammals and the nematode.
This observation reveals that the role of Rrp6 in the nuclear retention of defective transcripts is not restricted to yeast but is conserved in insects, and probably in all metazoans.
The GATA transcription factors bind a consensus A/T-G-A-T-A-A/G sequence in promoters and are conserved in insects and vertebrates, from fly to humans [19].
Furthermore, some key positions in the LBD signature domain and other regions that are conserved in insects and vertebrates have diverged in Caenorhabditis (Additional file 2: Figure S2).
Conserved intron/exon structures and microsynteny further support the conclusion that these steroidogenic CYPs have been conserved in insects and crustaceans through some 400 million years of evolution.
We therefore conclude that CenpS and CenpX are conserved in insects due to their role in DNA repair (Singh et al., 2010), rather than as kinetochore components due to the absence of their binding partners CenpT and CenpW.
The E spl -C architE spl -Cdomarchitecturalolutionarily significant, because Notch-regulatedomainncer of split comayexes with similar structures are conserved in insects and crustaceans over 420 million years (Maeder et al. 2007; Duncan and Dearden 2010).
The functional class of ILPs represented by DILP6 may be conserved in other insect species, as an ecdysone-induced, fat-body-specific ILP has recently been described in Bombyx mori (Okamoto et al., 2009).
First, Tribolium miRNAs are more likely to be conserved in other insects than Drosophila miRNAs.
