While the predicted H. pylori tmRNA structure and essential residues were conserved in comparison with those of the well-studied molecule of E. coli, the tag sequence of H. pylori presented some striking differences.
In the analysed teleost species no SCD5 is found, while the surrounding SCD5-less locus is conserved in comparison to tetrapods.
In addition to these two regions, a sequence immediately upstream of exon 1 of the human ghrelin gene is conserved in comparison to mouse sequence (Fig. 1A).
In these models, many additional immune responses are conserved in comparison to humans, from an even more similar innate immunity to the adaptive immune response in mice and (adult) zebrafish.
As expected, the two C. pseudotuberculosis strains showed high synteny conservation; approximately 97% of their genes were found to be conserved in the comparison between the two strains.
Of 696,016 microsatellites identified in human aligned sequences, 594,340 (85.39%) were found to be conserved in at least one comparison species, whereas 199,403 (28.65%) and 41,608 (5.98%) were conserved in at least one and three nonprimate species, respectively (supplementary table S3, Supplementary Material online).
Requiring either the upstream or downstream Met to be conserved in at least half of the comparisons to proteins from the reference species proteins dataset returns 30,953 proteins.
In comparison, we found only eight of these tandem duplications to be conserved in E. cymbalariae (Table S3A).
This mechanism may be conserved in many organisms.
However, although helix II was conserved in the comparison with the one from A. salina, a nucleotide substitution (G/A) in position 61 was found in some sequences.
