Functional specificity of proteins is assumed to be conserved among orthologs and is different among paralogs.
Curiously, residues involved in both 'activator' and 'receiver' interfaces (both N-lobe and C-lobe) are conserved among all active kinases HER1, 2 and 4 [ 39 ], suggesting that these can act as both 'activators' and 'receivers'receivers
Sequence comparison demonstrated that all the residues involved in Ca2+-binding and substrate recognition in the active site are conserved among the characterized protozoan nucleoside hydrolases.
The active site residues are conserved among the three PyNPs.
The pCAR1 plasmid contains divergent repA and parWABC genes for its replication and active partitioning, which are conserved among IncP-7 plasmids [ 10, 21, 22].
Many orphan GPCRs are conserved among different species suggesting that they should be active and thus bind novel ligands.
Studies in Drosophila have also revealed histone hyperacetylation at active origins, a modification that is conserved among different Drosophila species (32).
Moreover, all the active site residues of β-mannosidase are conserved among all the species involved in this study.
Although the active site of this class of hydrolases is conserved among bacteria and vegetal ureases, the same is not observerd for allosteric site.
