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Association studies increasingly implicate KIR in disease predisposition and outcome but could be confounded by unknown KIR genetic structure in heterogeneous populations.
The cross-sectional design does not infer causality and the associations described may be confounded by unknown and unmeasured factors.
However, the observed overall association between ever smoking and breast cancer could be confounded by unknown factors.
Unlike our study, 97% of their 457 ovarian cancer cases were postmenopausal and the authors state that their results could be confounded by unknown factors.
As the authors of the post-hoc analysis of the DIGAMI-2 trial themselves point out, there is the strong possibility that results may be confounded by unknown covariates, and in a complex disease such as diabetes this is a common concern.
The absence of any differences in the primary outcome of central fat by DEXA could be real due to a lack of sensitivity in DEXA's precision to measure central fat or may be confounded by unknown differences in the much smaller cohort.
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This is likely to be a chance finding, as only nine of 130 units reported no intensivist participation, or it may be confounded by an unknown characteristic in those nine units.
Lastly, we did not record tobacco use among our sample, and given the reported link between cigarette smoking and panic attacks [ 72], our results may be confounded by smoking in unknown ways.
In our case the finding could also be confounded by high number of unknown dates and ascertainment of correct date was not possible.
It is well known that even well-conducted, well-controlled epidemiological associations can often be confounded by imperfect measurement of known, or unknown, related factors.
Potential exposure assessment can be confounded by behavioral risks, genetic propensity, and unknown environmental risks, as well as the dynamics (intensity and duration) of the studied environmental exposure.
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be confounded by concurrent
be affected by unknown
be mediated by unknown
be influenced by unknown
be monitored by unknown
be confounded by genetic
be confounded by urban/rural
be limited by unknown
be confounded by important
be caused by unknown
be confounded by unmeasured
be confounded by concomitant
be confounded by extensive
be explained by unknown
be used by unknown
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com