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Comparisons between hospitalized patients and healthy controls, for example, are likely to be confounded by medication and common cardiovascular risk factors.
It is worth pointing out that the observed association between advanced age and multiple comorbidities infection, and the increased risk of CDI, may be confounded by medication exposure given that polypharmacy is common among these groups of patients.
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Although performance was related to self-reported or caregiver-reported medication management in all four studies, again this could be confounded by lack of medication familiarity or practice for those not managing their own medications.
The advantage of focusing on youth is that the results will not be confounded by obesity comorbidities or medication use, both of which are very common in adult subjects with obesity.
However, while the experimental within-patient fMRI studies are more likely to reflect causal medication effects, the retrospective structural MRI analyses could be confounded by other discriminating factors than medication status and need corroboration in prospective longitudinal within-patient MRI studies.
Our findings regarding the effects of current medication may be confounded by the fact that most patients are treated with more than one class of psychotropic medication.
However, the increase in use of such medications between study baseline and the 3-month time point was small and not statistically significant and so the vascular changes observed over that period are not likely to be confounded by changes in these other medications.
Cardioprotective effects of dietary omega-3 PUFA might be confounded by the use of cholesterol-lowering medications: in the GISSI-P study only 5% of participants were on a cholesterol-lowering drug [ 18], which is in strong contrast to the ORIGIN omega-3 PUFA study, where approximately half the patients were on a statin [ 23].
However, medical therapies are not considered in the current analysis, since the effects of medications on vascular complications were likely to be confounded by other clinical factors.
If not, the estimates will be confounded by omitted variables.
One possible explanation for these conflicting findings is that the results are confounded by antipsychotic medication.
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