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Of 53 papers published at Amgen, results could only be confirmed in six (11percentt) of the cases.
This claim could not be confirmed in five independent follow-up studies [ 7- 11], despite target engagement.
A suspected diagnosis was confirmed in three patients.
Phenotypes were confirmed in three independent experiments.
This was confirmed in three individual samples and five fields.
siRNA experiments were confirmed in three independent experiments.
This tendency was confirmed in three independent experiments.
All EMSA results were confirmed in three independent biological replicates.
Luminal expression of SNAP25 was confirmed in three out of three patients and basal expression of TEAD1 was confirmed in two out of three patients.
INPP4B-mediated changes in expression of all four genes were confirmed in three independent experiments.
This was confirmed in three individual semen samples and five fields of view.
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