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Epidemiological research on symptoms or injuries can be conducted using clinical records, nationwide surveys or questionnaires.
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Tanner stage assessments for pubertal onset were conducted using clinical examination by trained clinic staff based on standardized methods, which is considered the gold standard in the field [ 13].
For example, much of the research into childhood headaches is conducted using clinical samples from speciality headache centres.
Furthermore, none of the previous validation studies [ 10, 11] were conducted using clinical trial samples.
Although one study examined the validity of MFQ in a mixture of children from clinical settings and the community, most studies have been conducted using clinical samples [ 14- 17].
This prospective observational study was conducted using clinical and routine laboratory data collected from the Clinical Microbiology Unit of the General Hospital of Perugia, Italy, from March to September 2014.
Metabolic analyses were conducted using clinical biochemistry methods, two distinct MS-based platforms (targeted and non-targeted), and NMR spectrometry (lipid classes and binned spectral data).
With two exceptions [ 75, 83] all of the studies which have investigated QoL in children or adolescents with ADHD have been conducted using clinical samples of referred children.
This study was conducted using clinical and laboratory data from a single-center analysis of GBS UTI in patients at University of Alabama at Birmingham (UAB Hospitall conducted between August-2007 and August-2008 [ 14].
This can only be conducted using specialized equipment, often in a clinical research facility, under the supervision of a doctor or nurse.
Early clinical trials can be conducted using formulations with limited short-term stability manufactured on a small scale.
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