The feasibility study was conducted specifically in the epilepsy field.
For him, the relevant issue was not whether the bombing was conducted specifically in order to kill people (motive) but whether it could be reasonably expected to do so.
As yet, no study has been conducted specifically in older men, but the toxicity profile of radiopharmaceuticals appears appropriate for administration in these patients.
The rarity of this disease has resulted in a limited amount of clinical data; indeed, very few clinical trials were conducted specifically in male patients and, conclusions concerning treatment strategies therefore have been generally drawn from trials conducted in female patients.
(The CHARISMA trial also included patients at high risk for cardiovascular events as defined by the presence of multiple risk factors, but only patients with established cardiovascular diseases were included in the smoking subgroup analysis. 10 11) One was conducted specifically in patients scheduled to undergo percutaneous coronary intervention.
The role of gene expression analyses such as Oncotype Dx (Genomic Health, Redwood City, CA, USA) and Mammaprint (Agendia BV, Amsterdam, The Netherlands) to help identify those most likely to benefit from adjuvant chemotherapy may be of particular help in older patients, but to date no studies have been conducted specifically in this age group.
Currently, one clinical trial of an Hh inhibitor has been conducted specifically in breast cancer, with GDC-0449 used in combination with a gamma-secretase inhibitor to treat women with advanced breast cancer (NCT01071564), but this trial has been suspended owing to side effects associated with this particular combination therapy.
Little research has been conducted specifically on distress in young adults (individuals between 18 and 30 years of age) with diabetes [ 4], though distress is also considered to be prevalent in this age group [ 23].
