Sentence examples for be compromised upon from inspiring English sources

It has been suggested that the activity of the proteasome can be compromised upon aging [14] and diabetes [15].

A recent report illustrated that tissue compartmentalisation boundaries within the PSU can be compromised upon perturbation of the Notch pathway (Veniaminova et al., 2013).

Therefore, as in the case of deletion of the entire domain, both the phosphotyrosine-binding function as well as the maintenance of the SH2-kinase domain interface are likely to be compromised upon introduction of the Arg171 mutation.

Due to the ability of the viral mimic to suppress expression of these probes, it is possible that their putative functions as occurring in survivors and carriers may be compromised upon subsequent viral challenge.

However, typical electrochemical investigations of flavoenzymes are at times hindered by the stability of the flavin-bound form of the protein: protein binding of the flavin cofactor can be compromised upon exposure to a typical graphite working electrode frequently used in PFV experiments, as has been reported for flavodoxin and P450BM3.

However, these steric protection effects are compromised upon systemic administration due to low retention of PEGylated lipids within liposome membranes upon dilution.

HR DNA repair is compromised upon HDAC inhibition, owing to both downregulation of HR repair proteins, and impaired recruitment of these proteins to the damaged site.

Recruitment of key HR repair proteins to the site of DNA damage, as well as HR repair capacity was compromised upon HDACi treatment.

To determine whether DNA damage signaling is compromised upon RECQ1 depletion, we examined the DNA damage-induced G2/M checkpoint in RECQ1 siRNA-treated cells.

To determine whether the DSB repair is compromised upon HDAC inhibition, we employed H2AX foci clearance as an indicator of efficient DSB repair.

Using sensitized genetic backgrounds and specific reporters we find that insulin signaling is compromised upon depletion of tomm-40 and that this is due to a decrease in DAF-28 secretion.