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Before 2006, oseltamivir-resistant seasonal A/H1N1 viruses were found to be compromised for replication and transmission in vitro and in vivo, compared to the corresponding wild-type [18], [19].
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Moreover, Orc6 constructs lacking part of the C-terminal domain are compromised for initiating DNA replication in Drosophila extracts (Balasov et al., 2007).
Once you're compromised, you're compromised for life.
For example, 'Socialization is compromised for lack of verbal skills.
However, the question still remains whether the neurons that receive high numbers of genomes would have survived infection with WT virus because TK mutants are severely compromised for replication in neurons.
However, in exchange for high specificity, sensitivity may be compromised.
Increased proliferation when DNA replication is compromised can result in high levels of apoptosis (Sampath et al. 2003).
or endogenous (primarily transposons) agents, and/or that such tissue is compromised in the repair of somatic replication error.
Fragile sites are secondary structures in chromatin that challenge replication, particularly under conditions in which the efficiency of the DNA replication machinery is compromised [ 79].
Once the integrity of the replication fork is compromised, the DNA damage checkpoint pathway is activated.
This allows the selection of polymerases under conditions where catalytic activity and processivity are compromised to the extent that full self-replication is inefficient.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com