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Poliovirus type 1 strain Sabin, reverse-engineered to contain this substitution, proved to be completely insensitive to the antiviral effect of H1PVAT and was cross-resistant to the capsid-binding inhibitors V-073 and pirodavir.
As indicated in Figure 4B and C, they appear to be completely insensitive to i.t.
Indeed, phosphorescence of porphyrin 2 was found to be completely insensitive to C307, even when the latter was present in millimolar quantities.
Resistant viruses were assumed to be completely insensitive to oseltamivir, and therefore prophylaxis had no effect on the susceptibility of a person who was exposed to a resistant strain.
Not even the most convinced advocates for a certain principle are likely to be completely insensitive to the size of the sacrifices one has to make when principles clash.
After 4 weeks of treatment, 16 resistant clones were isolated and confirmed to be completely insensitive to compound 146 at up to 10 μM following 72 h treatment by an ATPase-based viability assay (CellTiter-Glo).
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Here, by sequence alignment analyses of the human KCNQ1 channel and scorpion potassium channel MmKv2, which is completely insensitive to scorpion toxins, we proposed that the insensitivity mechanism of KCNQ1 toward natural scorpion toxins might involve two functional regions, the turret and filter regions.
"These funds, because of the insurance wrappers, are completely insensitive to interest rates," said Eric M. Jacobson, a senior bond fund analyst at Morningstar Inc.
Unlike the SSVO, the DCVO is completely insensitive to an accelerometer offset.
One of the main advantages of this technique is that it is completely insensitive to the damping coming from the boundary conditions.
Furthermore, (ULambda^{-1}U^{dagger}) is a constant matrix that is independent of the system parameters, which indicates that at high temperature the quantum simulation is completely insensitive to the nominal values of the underlying parameters.
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