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Though SiCYS, SiCYS-N or SiCYS-C was purified to high purity by two different affinity columns, it could not be completely excluded that the antifungal effect might be also partially resulted from the trace contaminant in the purified protein.
Alternately, it cannot be completely excluded that the unrelated-related difference reflects a difference in post-access processing that is mediated by the same structures across common/proper nouns that are instead stored in different areas.
However, since this domain also contains stretches of histidines, as well as other sequence motifs, mediating interactions with Zn2+ and Cu2+, it cannot be completely excluded that additional antimicrobial effects of PrP may be mediated by this region, particularly at low pH and perhaps in concert with contributions from additional helical motifs in the globular part.
Since data on non-cardiovascular co-morbidities are also missing, it can also not be completely excluded that the observed associations may be driven by unknown confounding factors.
At present it cannot be completely excluded that part of the observed responses, especially related to transcription and protein biosynthesis, are due to the reduced growth rate of the ccw12Δ mutant (approximately 25% less than wt).
It cannot be completely excluded that all unknown samples in group B showed a transcriptomic profile similar to positive controls for other reasons than being treated with anabolic hormones.
Similar(45)
It cannot be completely excluded however, that some of these line-specific differences are due to undirected allelic drift as a consequence of genetic separation of both lines over many generations.
Finally, the role of inflammation cannot be completely excluded since inflammatory pathways that do not include IL-6 and CRP can lead to high ferritin concentrations [ 41].
Although disease acquisition from a patient residing in another state or from exogenous reinfection could not be completely excluded, we assumed that these events were rare (18, 19).
Thus, it cannot be completely excluded the possibility that HECTD3 promotes cell survival partially by targeting Tara and/or Syntaxin-8 for degradation.
As opposing results could not be completely excluded, a further examination is needed that could lead to a more complete understanding of the topic.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com