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For F3 cells to be a suitable vehicle for the generation of transgenic mice they should be competent to generate chimeric mice that can transmit alleles through the germline.
To assess whether the lack of an ex vivo response in HuD+/+ mice was due to ineffective immunization, splenocytes stimulated in vitro with p321 were assayed and found to be competent to generate activated HuD p321-specific CD8+ T cells (Fig 3d).
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These iPS cell clones appear to be equivalent to embryonic stem cells in gene expression and are competent to generate germline chimeras.
In summary, neuronal progenitors are competent to generate neurons upon exposure to Tgfβ over the entire culture period, where upon a minimal time frame of 2 3 days is necessary to detect changes in the expression of differentiation markers.
Early cortical progenitors are competent to generate late-born neurons after transplantation into older hosts, indicating that they can respond to later environmental cues, but progenitors become progressively restricted in their ability to populate different lamina as neurogenesis proceeds (Lui et al., 2011).
Similarly, it has to be competent to be credible.
In the process of SG renewal, SCs of the HF bulge generate progeny, which are competent to move upwards to replenish the SG and potentially the infundibulum of HFs.
The mature INP is competent to undergo several rounds of asymmetric divisions, each time generating a self-renewing INP and a GMC [ 27, 65, 66].
"I am not sure I am competent to do that.
Training programs must ensure residents are competent to practice independently.
He's competent to make that decision.
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