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Notably, this signature is absent from the inner ARM-repeat α-helices of Syo1, which should therefore not be competent to bind monopartite or bipartite cNLSs.
In the present study, module 1 was assembled independently and was found to be competent to bind base-CP, however in the crowded milieu of the cytosol, other assembly pathways may exist in parallel.
Structure-directed functional studies show that authentic MAL regulation requires that each of the three RPEL motifs in the N-terminal regulatory domain be competent to bind G-actin.
Similar(56)
Conformational states that are competent to bind immune-stimulating FcγRs interconverted with Fc conformations distinct from those observed in FcγR complexes, which may represent a transient, nonbinding population.
The openings are found in the active conformation, in which opsin is competent to bind and activate the G protein transducin.
Thus deletion of this region, as found in BDB mutants, yields a receptor which is competent to bind Wnt ligand but unable to produce a productive tyrosine phosphorylation signalling response.
While we found that there are substantial amounts of kermit2 in Xenopus embryos our GST pull downs and coimmunoprecipitations suggest that only a small fraction of kermit2 in the embryo is competent to bind to endogenous α5β1 integrin.
While all Skp1 isoforms were competent to bind Fbs1, glycosylated glycoforms bound preferentially.
Overall, our comparative analysis supports the prediction that the RGG box of Sho is competent to bind RNA.
Alternatively one kinetochore might be "silenced" so that only one kinetochore between the two sisters is competent to bind microtubules.
While it has been established that PrP is competent to bind nucleic acid, it is also known to bind many other ligands including polyanionic glycosaminoglycans ('GAGs').
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com