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In many cases, the radiological development of avascular necrosis may be compatible with normal activity.
Further, because this erasure is confined to primordial germ cells, we anticipate that its disruption would be compatible with normal somatic development.
Heat inactivation of FBS for nuclease removal does not appear to be compatible with normal cell growth.
The inverted orientation of the 1.2 Mb duplication would be compatible with normal imprinting because the KCNQ1 promoter is included in this chromosomal imbalance.
Hence, we predict that, depending on the co-existing genetic milieu, the A569T variant may cause NKH, predispose to NTDs or be compatible with normal development.
This suggests that natural genetic variants that are shaped by selection can both provide protection against protein aggregation and toxicity, and, at the same time, be compatible with normal development and physiology.
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Alkaptonuria is compatible with normal life expectancy.
Importantly, all approaches to knockdown tmem33 function were compatible with normal gross embryonic morphology at phenotypic doses (Supplementary Fig. 11).
There are no other clinical manifestations or disabilities, and the condition is compatible with normal life expectancy.
However, all of these germline mutations are compatible with normal vascular development.
This is compatible with normal camera placement for other currently emerging automotive vision applications such as traffic sign recognition and obstacle detection.
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