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Data with repeated points, such as blood glucose concentrations, will be compared using mixed model techniques, modelling the main effect of treatment group allocation, time and their interaction, with significant main effects and interactions tested using the method of Tukey.
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The incidence of postoperative complications and mortality will be compared using Fisher's exact test, while the above laboratory measures will be compared using mixed-effects models with a subject-specific random intercept.
Changes in the dependent variables were compared using mixed model analysis (limb versus age).
Biochemical markers were compared using mixed regression models to take account of the repeated measures, adjusting for preoperative measurements of the markers and participating centre.
Respiratory periods, the distribution of time lag between inspiratory and expiratory burst peak times, the effect of time lag on the amplitude of respiratory bursts and percentage of respiratory deletions were compared using mixed random effects ANOVA with mouse as the random effect and least-squares mean values were determined.
The change of PHQ-9 score and the two SF-12v2 component scores among the initially screened PHQ-9 positive subjects who had and had not been identified with depression by study doctor at baseline were compared using mixed models for dealing with missing data.
Outcomes over time were compared using mixed-effects regression models with the individual as the random effect.
Sedation levels were compared using mixed-model repeated measures analysis of variance (ANOVA; for RASS variable) or a generalized estimating equation (for the awake variable) model [ 14].
Continuous data were compared using mixed-effects analysis of variance (ANOVA; for groups and subjects over time) with the post hoc Bonferroni Dunn correction, as appropriate.
Intervention and usual care periods will be compared using a linear mixed effects model for continuous outcomes and a generalised linear mixed effects model for binary outcomes.
Aiming to assess the non-inferiority of facilitated access compared with standard face-to-face intervention, the proportion of risky drinkers in both groups will be compared using generalised non-linear mixed models.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com