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SMARTS can be compared to query formalisms such as the Markush structure encoding formalism commonly used in patents [43] and the Molecular Query Language [44].
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It is a process whereby gene expression profiles of cell-line response to drugs are compared to query gene signatures, in order to evaluate similarity and identify potential drugs able to alter the gene signature's expression [ 5].
RetroGuide could then be compared to cohort estimation (or query building) tools such as i2b2's query component [ 45] or STRIDE (a proprietary patient cohort discovery tool developed at Stanford university [ 46]).
This would decrease search times where the query would be compared to the smaller and more likely database and if there is not a match, it would be compared to the second database [11].
A query can be compared to ad-hoc families by running BLAST against the seeds of the ad-hoc families, which is much faster than running BLAST against the entire database (data not shown).
For this reason we suggest using BLAST or SSAHA2 for exploratory sequence comparison since trial-and-error databases can be created and destroyed rapidly, but to select Simrank for persistent datasets where various queries will be compared to a fixed set of sequences.
We retrieved GO http://www.geneontology.org/ annotations as assigned to the unigenes in the microarray probe data set and used Fisher's exact test as implemented by Blast2GO to check for enriched GO categories when the tests sets were compared to the total query [ 86].
After each move, the distance of the newly described cavity descriptor is compared to that of the query, the best alignment having the minimal distance between both cavity fingerprints.
When a query was compared to the database, each matching hash was linked to offset time pairs between the offset times of the beginning of the query song and the song in the database.
This query is compared to the descriptions of the stored images in the repository, using traditional text retrieval techniques.
In our discussion, we require such alignments to be semi-global; in such an alignment the entire query is compared to a subsequence of the target.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com