Sentence examples for be commonly mutated in from inspiring English sources

Diagnostic peripheral blood or bone marrow samples from NPM1-mutated AML patients (n = 120) were subjected to targeted sequencing using a panel of fifty-seven genes known to be commonly mutated in myeloid malignancies.

PIK3CA gene that encoded the catalytic p110-alpha subunit of PI3K has been described to be commonly mutated in various cancers, including colorectal cancer [ 8].

Other genes known to be commonly mutated in human CCA, such as KRAS, have yet to be fully explored in modelling work (Hezel et al., 2010).

Another interesting observation was MYC, TP53, KRAS, and BRCA1, genes reportedly to be commonly mutated in cancers but did not show significant association between copy number and gene expression.

Recently, individual splicing factor genes have also been found to be commonly mutated in different cancer types, and this has been shown to have important implications for carcinogenesis [ 30– 39, 39, 40].

The gene encoding tumor suppressor p53 is commonly mutated in cancers, and contrary to the EGFR mutation, p53 mutations occur more frequently in smokers than in non-smokers (Ryberg et al., 1994; Garinis et al., 2001; Pfeifer et al., 2002).

Upstream negative regulators of mTORC1 are commonly mutated in cancer and, indeed, inactivating mutations in GATOR1 genes are found in in a subset of glioblastoma and ovarian tumors.

While EGFR (epidermal growth factor receptor) is commonly mutated in adenocarcinoma of never smoker patients, the mutations in other genes are much less common than in the smoker patients [ 2].

Although TNNT2 is commonly mutated in HCM, surprisingly, it has been found that distinct TNNT2 mutations also lead to DCM [2].

We have demonstrated that an Fbxw7 propellor tip mutation at arginine 482 a site homologous to amino acid 479 that is commonly mutated in human tumours directly promotes intestinal tumorigenesis in a mouse model.

PIK3CA is commonly mutated in both Type I and Type II cancers.