Overall, this study suggests that there are common pathways of epigenetic dysfunction in distinct models transformed by arsenic, cadmium or MNU, which target both individual genes as well as larger chromosomal regions that contain many genes.
Based on our results, when the reduction of CYP11A1 level decreases cell proliferation (as seen in PA cells), both apoptosis and p21 expression are also involved, indicating that these are common pathways downstream of CYP11A1 signaling.
The formation of TIAs precursor involves the shikimate pathway of tryptophan metabolism and MEP pathway which are the common pathways of terpene biosynthesis.
There are no effective treatments for repair of the damaged articular cartilage in these diseases and while their likely aetiologies are very different, common pathways of degradation are important in both.
Reactive oxygen species and cytosolic calcium seem to be common triggers of signaling pathways that result in these beneficial effects.
The above evidence supported our predictions that alteration and disruption of these pathways may be common features of NDs.
75 Although tissue-specific features of fibrogenesis appear to exist, there is increasing appreciation of common pathways of fibrosis that are conserved among tissues, including TGF-β, connective tissue growth factor, interleukins 4 and 13, platelet-derived growth factor and osteopontin.
As cellular senescence is a common pathway of many cell lineages other than MSCs, it is possible that Tat and Nef could induce senescence of several other cell types, as hematopoietic stem cells.
One possibility is a common pathway of osmophobia and mood changes may provoke suicidality.
In this report, we have hypothesized that α7 nAChR -mediated signaling is a common pathway of CNS disorders caused by C. neoformans, HIV-1 virotoxins (gp41) and METH.
