Sentence examples for be closely implicated in from inspiring English sources

As an anti-apoptotic protein, API5 may be closely implicated in the regulation of apoptosis and is highlighted as a potential drug target in cancer.

As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown.

Retrotransposons are known to be closely implicated in genome reshaping [ 1], but Miniature Inverted-repeat Transposable Elements (MITEs) could also be implicated, since they have very high copy numbers and display recurrent bursts of transposition [ 2, 3].

These results suggest that the cell cell contact between carcinoma cells and normal fibroblasts enhances the production of MT1-MMP followed by sequential activation of proMMP-2 on the tumour cell surface, which may be closely implicated in tumour invasion in vivo.

In short, our discovery conformed to previous findings showing that resistin expression may be closely implicated in the pathogenesis of OA, suggesting that the detection of expression levels of resistin may be valuable in the early prediction of disease severity and prognoses of OA patients for the purpose of avoiding poor clinical outcomes.

In summary, the discovery of the represented meta-analysis was in conformity with previous studies that LRP5 rs3736228 C>T polymorphism might be closely implicated in the pathogenesis of bone fracture and osteoporosis, implying that this polymorphism may be a helpful biomarker in predicting the occurrence of bone fracture and osteoporosis.

As an assisted witness, Ms. Lagarde has not been placed under formal investigation but is considered to have been closely implicated in the case, which involves a half-billion-dollar state payout to Bernard Tapie, a businessman and politician who once served time in prison for his involvement in the fixing of soccer matches.

Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis.

Abnormal expression of γ-Glutamyltranspeptidase (GGT) in living organisms is closely implicated in the development of several human tumors.

The SIRTs have been closely implicated in both protection against and generation of cardiac disease [ 65- 68] (Table 2).

These neurons are closely implicated in descending bulbospinal inhibitory control, and such loss may upset the natural endogenous pain-suppressing mechanisms.