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The disulfide bonds at the junction points can be cleaved by a reducing agent, resulting in aggregation of the assemblies.
Most importantly the protein component can be cleaved by a diverse series of proteolytic enzymes and the glycosaminoglycan component, in particular the HA, is susceptible to the action of glycosyl hydrolases.
However, in highly virulent strains, such as H5N1, the hemagglutinin can be cleaved by a wide variety of proteases, allowing the virus to spread throughout the body.
Not all proteins with accessible sites will be cleaved by a protease.
The two polyproteins expressed are predicted to encode and to be cleaved by a papain-like proteinase 2 (PL-Pro = part of nsp3) and a 3C-like proteinase (3CL-Pro = nsp5) to 16 mature replicase proteins [1], [6].
At this position, a pathogenic NDV strain (velogenic and mesogenic) has at least one extra pair of basic amino acids motif 112X-R-X-R/K-R-F117 [20] and cleavedcleaved by a wide range of proteases of the furin family in different host cells [21].
Similar(39)
Disulfide bond, which is abundant in the peptide and protein, can be cleaved by an intracellular reducing molecule, GSH, while it is stable at the extracellular environment [30].
To test this hypothesis, antigen-adjuvant conjugates were designed to be cleaved by an intracellular trigger to release antigen and adjuvant from each other.
If the lesion occurs in leading strands, stalled replication forks can be cleaved by an endonuclease, leading to the creation of a one-sided DSB.
APP can be cleaved by an alternative α-secretase rather than β-secretase in the first step to circumvent the generation of pathological A β peptide.
No attempt was made to differentiate between signal peptides (which are cleaved by a SPase) and signal anchors (which are not cleaved) for these sets.
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