It was quite remarkable that anyone could take the outer movements of the Beethoven and the Chopin at such a clip and still be clear, musically functional and never out of breath.
First, while there would be clear functional evidence of disease when a biologic network succumbs to an abnormal attractor, the structure of the network and its individual components would remain completely normal.
The actual biological cross-talk will be clear after extensive functional studies for mRNA:miRNA interactions.
Because small GTP-binding proteins modulate nearly every cellular activity, it is clear that functional inhibition from members of this protein family influences growth and differentiation of normal cells as well as of tumor cells [3,5,7,9 11].
The presence of many functional loci was shown, together with a pseudogene family and putatively non-functional alleles; there was clear evidence that functional alleles were under strong balancing selection.
Thus, there are clear functional relationships between and among genes acting within a signaling pathway by molecular mechanisms such as protein-protein, protein-DNA and protein-RNA interactions, etc (Fig. S1).
As it is clear, the functional verbs included in the cluster (e.g. measure, check, abrade) were instrumental in understanding the relations between the objects described by substantive keywords.
In addition, it is clear that functional approaches are also necessary to fully understand the role of a given gene in a particular biological process.
While the specific roles of BRCA1 continue to be clarified, it is clear that functional BRCA1 protein is required to prevent breast transformation.
In the three core components Hippo, Warts and Mats, it is clear that all functional domains are under purifying selection and most regions under purifying selection are functional domains.
