Sentence examples for be characterized by mutations from inspiring English sources

Another sub-type that emerges from both mRNA and methylation profiling appears to be characterized by mutations in BAP1 and TP53.

Additionally, this sub-type seems to be characterized by mutations in the PBRM1 gene which is located close to the VHL gene in the 3p region [ 25].

The invasive stages of tumorigenesis are thought to be characterized by mutations involving tumor suppressor genes like TP53 or PTEN, alterations that allow cancer cells to circumvent programs that limit proliferation (e.g., the cell-cycle checkpoints, which operate more efficiently in early-stage tumors, as discussed above).

Familial hypobetalipoproteinemia (FHBL) is characterized by mutations in APOB, the majority of these causing protein truncations, and low plasma levels of apolipoprotein (apo) B. The hypobetalipoproteinemia may be due to enhanced clearance and possibly reduced production of apoB-containing lipoproteins; the mechanism may depend on the length of the apoB truncation.

Subtype 8.2 is characterized by mutations in the tumor suppressor, p53.

Subtype 4.1 is characterized by mutations in NRAS, which are observed in approximately 20% of melanomas [46], [19].

This subtype is characterized by mutations in the c-KIT pathway/complex, a receptor tyrosine kinase (RTK) that regulates intracellular processes such as cell growth, division, and migration in response to Stem Cell Factor (SCF) activity.

High-grade disease is characterized by mutations in known cancer-associated genes and the p53 signaling pathway.

Since mto1 mutants are characterized by mutations involving the aspartate pathway, the approach based on graph-clustering proved itself useful for characterizing genotypes.

Whilst many of the above diseases are characterized by mutations in protein coding regions, mutations can also exert deleterious effects through RNA molecules.

This subtype is characterized by mutations in the ras homolog gene family, member A (RHOA) gene or fusions involving Rho-family GTPase-activating proteins (GAP).