The postneonatal period in the ROMK-defective children with BS was characterized by failure to thrive, hypercalciuria, nephrocalcinosis, and minimal-to-no hypokalemia.
The phenotype of ES (Dicer−/−) is characterized by failure to down-regulate master self-renewal regulators Oct4 and Nanog, failure to differentiate, and lethality at embryonic day E7.5 [21], suggesting an important role for miRNAs early in stem cell development.
Within the human population, there are several rare, hereditary, sensory and autonomic neuropathies (HSANs) which are characterized by failure in development of or by degeneration of primary sensory and autonomic neurons [2].
Disease is characterized by failure to adapt appropriately to such stressors [ 15].
In contrast, in hypomineralized AI there is near normal enamel volume that is characterized by failure of normal biomineralization.
The classical presentation is characterized by failure to thrive, diarrhoea, irritability, vomiting, anorexia, foul stools, abdominal distension and muscle wasting.
Achalasia is caused by loss of inhibitory enervation of lower esophageal sphincter and is characterized by failure of the sphincter to relax.
Additional 10 MS non-responder patients, which were characterized by failure to respond optimally from initiation of therapy as assessed by clinical measures, were recruited too.
