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Furthermore, the consequences of μ opioid receptor activation are so dissimilar in astrocytes from other cell types [59], that it would be challenging to predict the nature of converging opiate-Tat toxic signals without empirical testing in astrocytes.
This type of off-target effect will be challenging to predict because it requires limited homology and suggests the need for caution when expressing shmiRs at a high level.
It can be challenging to predict the risk of biochemical recurrence (BR) during follow-up after radical prostatectomy (RP) in men who have undetectable prostate-specific antigen (PSA), even years after surgery.
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The bank, Europe's largest by market value, said the outlook for 2005 was "challenging to predict" in light of issues like terrorism and uncertainty about the American economy.
It is challenging to predict the positions of side chains without its bound protein.
Consequently, the total effects of the bypasses are challenging to predict.
Due to the high randomness, it is challenging to predict the link quality in HSR wireless networks.
Since the governing equations are coupled and nonlinear, such a conclusion is challenging to predict based on the material parameters.
Acute kidney injury (AKI) after cardiac surgery is associated with poor outcomes, but is challenging to predict from information available before surgery.
Because of the complexity of the core geometry and gap configuration, it is challenging to predict the flow distribution in the VHTR core.
This methodology will be particularly useful for designing RCTs aimed at evaluating combination prevention interventions in community-based RCTs, wherein an intervention׳s effectiveness is challenging to predict.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com