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Parental participation is often advocated as important for school-based interventions, however, getting parents involved in school-based interventions appears to be challenging based on earlier intervention experiences.
Since ROS can be formed following exposure to exogenous stressors such as U, or through normal biochemical processes in various cellular components such as cell membrane, mitochondria, peroxisomes and endoplasmic reticulum, clear identification of the actual source of ROS production may be challenging based on transcriptional responses.
Locating the regions of the mt genomes associated with the replication origins (ORs, also known as control regions or A+T rich regions) for both "+" and "-" strands can be challenging based on a knowledge of the nucleotide sequence of mt genomes alone.
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Prosecutors considered indicting the city, with the Fire and Buildings Departments coming under intense scrutiny, but chose not to do so, citing concerns that the charges could be challenged based on sovereign immunity.
In fact, if the colonies had been located close to other bee attractive agricultural crops (as may occur in beekeeping) the results could be challenged based on dilution of residues.
It may however be challenged based on the aforementioned.
The concept of M type-specific protective immune responses has recently been challenged based on the observation that multivalent M protein vaccines elicited cross-reactive bactericidal antibodies against a number of non-vaccine M types of GAS.
The historical approach of the one-hit theory for DNA-reactive chemicals and the view of genotoxicity as an inherent property of a chemical are being challenged, based on a better understanding of the complexity of molecular mechanisms of mutation.
Recently, the wisdom of this approach has been challenged based on the ability of a Gram-positive bacterium to incorporate extracellular fatty acids and thus circumvent the inhibition of de novo fatty acid synthesis.
Read coverage was computed and genome annotation was challenged based on read distribution and coverage.
Indeed, the role of DNA damage as a cause of aging has been challenged based on evidence supporting the idea that aging is a systemic process [ 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com