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Although c-Myc and mTOR are known to be central regulators of comparable biological processes, this is the first study, to our knowledge, that has identified a set of genes that are targets of both c-Myc and mTORC1.
Many of these upregulated miRNAs appear to be central regulators of epigenetic-, synaptic signandneuroimmune-relatede-related processes (Nunez and Mayfield [ 4]).
MicroRNAs miR-34c-5p and let-7g-5p, in particular, appear to be central regulators of hub genes in the most significant ethanol-responsive gene modules.
To resolve multiple matches, we take the most significant TOMTOM prediction among matching TFs that are either upregulated in, or known to be central regulators of, the ChIP-ed cell type.
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Proteasomes are central regulators of protein homeostasis in eukaryotes.
FOXO transcription factors are central regulators of longevity from worms to humans.
FoxA transcription factors are central regulators of gut development in all species.
Matsumoto-Kitano, M. et al. Cytokinins are central regulators of cambial activity.
Cytoplasmic innate immune sensors, including NLRs, are central regulators of intestinal homeostasis2,3,4,5,6,7,8,9.
Ca2 +-dependent signaling pathways are central regulators of differentiated vascular smooth muscle (VSM) contractile function.
The ATR ATMM and Rad3-related) kinase and its downstream effector kinase, Chk1, are central regulators of the replication checkpoint.
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