Thus, FAPs appear to be central cellular determinants of disease progression in mdx mice and influence the response of dystrophic muscles to pharmacological interventions that promote endogenous regeneration and inhibit fibro-adipogenic degeneration.
As TRAIL receptor-2 regulation has been reported to be a central determinant of TRAIL sensitivity, overexpression of TRAIL receptor-2 was performed, but did not have an impact on the TRAIL response, arguing against a dominant role of TRAIL receptor-2 expression levels in the regulation of TRAIL sensitivity in our experimental setting (Supplementary Figure S1D).
The mPTP is considered to be the central determinant of myocyte fate following ischaemia/reperfusion injury, and cardioprotective signalling cascades are thought to converge on the mPTP to prevent opening and thus inhibit myocyte death.
It is thought to be a central determinant of the development of anaemia in chronic disease.
In one of these studies, HIF-1α was shown to be a central determinant of TN cancer stem-like cell chemo-resistance [ 27].
The reason I suggest looking for lessons from countries at similar levels of development, wherever in the world they might be, is that the level of development is a central determinant of which policy issues are important in which places.
As might be anticipated, optical precision is a central determinant of the quantitative accuracy and reliability that can be achieved with LRE quantification.
Note also that between-host trade-offs, which have been identified as central determinants of virulence evolution in heterogeneous host systems, have been estimated seldom (Ganusov et al. 2002; Osnas and Dobson 2011), and it is uncertain how generally they occur in multihost parasites.
These power differences between the sexes are most clearly manifested through IPV, and are a central determinant of safety of sexual encounters (16).
Constant reinforcement of the policy and its active promotion were regarded as central determinants of successful policies.
