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While primary hydatid disease of the spleen is rare, secondary splenic involvement can either be caused by systemic (i.e. haematogenous) infection or subsequent to rupturing of a hepatic hydatid cyst and abdominal spread of parasites [5, 6].
Significant yield loss or increase can only be caused by systemic risk, which means that the low yields indicated in the survey were the result of regional yield loss and the high yields were the result of regional yield increase.
This is not surprising in the context of multiple organ failure, which may be caused by systemic microcirculatory failure.
Refractive change can be caused by systemic illnesses such as Lupus erythematosus, thyroid deficiency, and diabetes mellitus.
Organ damage from excessive inflammatory responses may be caused by systemic cytokine levels [ 5] but theoretically may also be linked to organ-specific cytokine production.
In addition, cerebellar degeneration can be caused by systemic diseases such as diabetes mellitus [ 74], chronic alcoholism [ 75], or obesity with metabolic syndrome [ 45, 46].
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However, Haider and Storey [10] advised that in patients with rheumatoid arthritis stress fractures were caused by systemic osteoporosis.
Sepsis-induced encephalopathy is caused by systemic inflammation in the absence of direct brain infection and clinically characterized by slowing of mental processes, impaired attention, disorientation, delirium, or coma.
The pulmonary inflammation was caused by systemic injection of cationic carriers in mice.
Septic shock, the leading cause of intensive care unit mortality, is caused by systemic activation of the inflammatory cascade.
Various degenerative lesions were observed in liver, kidney, heart, and gonads, suggesting that death was caused by systemic failure.
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