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However, such differentiation could be caused by drift.
If there is a large distance between the compared areas, the same difference in frequency can be caused by drift or by selection.
In the results we divided the 28 TEs into: one group of 11 TEs with large differences in frequencies between the slopes, which we considered as putatively adaptive caused by natural selection, and to a second group of 14 TEs, which have small or no differences at all between the slopes, which may be caused by drift and weak selection and will be also temporary.
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Downstream rewiring, in contrast, can be caused by drifts in the peptide specificity upon mutation of the determinants of specificity (DoS) in kinase (or SH2) domains (Creixell et al., 2015 [this issue of Cell]).
Based on the selection procedures used, it was difficult to determine if this was caused by drift or selection.
In order to test whether the degree of male phenotypic differentiation (vocal and morphological characters) was caused by drift or divergent selection, we performed an indirect coalescent-based simulation method developed by Masta and Maddison [ 30].
This may well be caused by genetic drift acting differently on the different populations, e.g., the Heishui population may has been subject to a genetic drift, leading to a low level of genetic diversity.
The disappearance of the bubble was likely to be caused by plasma drift across the geomagnetic field line following the polarization electric field in the MSTIDs.
The fact that such methodologies fail to recognize an ortholog of an E. coli regulatory site in another organism (or assign the site to another TF) may be caused by genetic drift (divergence between sequence motifs recognized by orthologous TFs).
Since our method is alignment-free, it avoids problems that would be caused by imperfect alignments or 'motif drift' (Moses et al., 2006).
However, the observed differences between breed variations could be caused by both selection and genetic drift due to genetic bottlenecks for some breeds.
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