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This was likely to be caused by background difference between indica and japonica.
EL-NE fragment levels of 2 nM in the controls may be caused by background ECM remodeling combined with matrix effects from the serum.
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The events they detect are caused by background radiation, or the radioactive decay of atoms, which Baecker says is a complete non-deterministic and unpredictable process.
However, these mutations were in diverse genetic backgrounds (Figure 1B) and it could be argued that the phenotype was caused by background effects.
The internal standard method curve was prepared (Fig. 4 top)) monitored at the summit of curve, indicating nearly proportional relation (the error might be caused by the background).
As shown before, differences in the frequencies of anti-topo I antibodies in different studies might be caused by ethnic background [ 1, 11] or by different classification systems of SSc [ 1, 2, 12- 14].
For example, if a phenotype is found arising in both mutant and wild-type segregants of the target gene it is more likely to be caused by a background mutation.
This might be caused by different backgrounds in respects of ethnicity or microarray platform.
This can either be caused by a static background and a moving object, by a moving background and a static object, or by movement of both background and object.
Poor specificity of the IgM ELISA is also likely to be caused by a high background seropositivity rate in the general population in our setting.
In addition to sample numbers and statistical methodologies used, the large variation in heritability estimates may also be caused by the genetic background of the studied populations and the environmental exposures experienced (see ESM Table 1).
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