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Moreover, the reduced duty cycle seems to be causal for the reduced peristaltic efficacy seen in larvae.
We identified the kanamycin resistance gene and the transcription factor encoding rhaR gene to be causal for the growth defect in P. putida.
Despite many studies showed an association between migraine and patent foramen ovale, it is still not known whether its presence might be causal for the migraine pathogenesis and currently its closure cannot be recommended for migraine prevention.
These observations imply that either the tRNAs or Usf1 (or both) might be causal for the expression variation among this set of amino acid metabolism related genes.
In German Pointer dogs, a homozygous insertion of repetitive satellite DNA within intron 35 of LAMA3 was shown to be causal for the defect [10].
Interestingly, the genes with transit sequences have trans-eQTL that map within 200 kb of Tomm40l, suggesting that this gene might in fact be causal for the eQTL mapping to this sub-region.
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All but three of our 20 candidate genes were causal for the blue module, with an average causality score rank of 25.
These models prove that mutations in PFN1 associated with ALS are causal for the disease and provide an extraordinary opportunity to study how PFN1 mutations confer neurotoxicity.
It is possible to identify a single or a few variants that are causal for the phenotype of interest, and to identify genes acting in pathways previously unknown.
Such an increase in headache has not been demonstrated for glatiramer acetate [21], underlining the theory that it is a specific effect of interferon beta which is causal for the increased headache frequency.
One hypothesis explaining these findings is that a higher total dosage of CM mutant protein is causal for the increased disease severity [9].
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