However, TatE is capable of substituting for TatA [46], although the structures of TatE complexes are very different to those of TatA complexes [12].
Many of the so-called T4-like bacteriophages encode Gp31 homologs, some of which are capable of substituting for the E. coli GroES protein in host function (Ang et al. 2000; Ang et al. 2001; Keppel et al. 2002).
Despite the minor impact of ets21c LONG knockdown on suppressing ras V12scrib tumors, Ets21cLONG is the only one of the tested TFs that was capable of substituting for loss of scrib in inducing malignant clonal overgrowth when overexpressed with oncogenic RasV12 in EAD.
2006), which supports the idea that secreted Wnt proteins act on the cell surface; however, if Wnt8 is capable of substituting for the dorsal determinant, it is reasonable to hypothesize that the Wnt8 protein acts in a cell-autonomous manner within the cell.
The second β-lactam resistance mechanism is mediated by proteins which are capable of functionally substituting for PBPs, but have much smaller affinity to β-lactam molecules.
Transgenic Drosophila expressing human PACT were generated to determine whether PACT is capable of functionally substituting for the Drosophila dsRBP R2D2, which has a well-defined role in small RNA biogenesis.
However, the conserved histidine residue present in the WH domain of NALP2, NALP4, and NOD1 may still be capable to substitute the function of Sensor 2. The GxP signature is a conserved motif located in the small helical subdomain (C-domain) [18] at the C-terminal region of the NACHT domain (Figure 1) [19].
