It is one of few aptamers known to be capable of modulating gene expression in vivo.
Further, the engineered β-cell must be capable of modulating its function in response to physiological changes such as puberty, pregnancy and aging, and to more short-term challenges such as infection, exercise and weight fluctuation.
Notably, these alginate-based bioinks were shown to be capable of modulating proliferation and spreading of hADSCs without affecting the structure integrity of the lattice structures (except the highly degradable one) after 8 days in culture.
In particular, more than 500 natural products appear to be capable of modulating the activities of kinases, transcription factors, and cysteine caspases, which are responsible for the pathogenesis of human cancers by affecting the cellular signal transduction, the expression of oncogenes, and apoptosis, respectively.
Thus, imatinib seems to be capable of modulating the BM microenvironment leading to conditions favourable to B cell differentiation.
In sum, the translocation data provide evidence that GR should be capable of modulating gene transcription as early as 10 minutes after treatment and that FSK treatment does not interfere with translocation related mechanisms.
