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Supra-physiological androgen levels appear to be capable of impairing attentional processing.
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Further study showed that TGFβ1 was capable of impairing the host immune response that was trigged by transplanted XANM.
In contrast to their effect on normal cells, nanoparticles are capable of impairing or killing cancerous cells [29].
However, it has also been shown that while inclusion bodies themselves do not impair UPS function [25], filamentous aggregates purified from HD brains are capable of impairing the 26S proteasome in vitro [37].
All are capable of impairing memory formation in mice and their formation and significant accumulation in the brain should thus be considered a potential cause of AD.
Inorganic arsenic is capable of impairing glucose-stimulated insulin secretion in cultured pancreatic β cells via the induction of oxidative stress (Fu et al. 2010).
Accordingly, Lp(a) is capable of impairing tissue growth factor beta (TGF- β) activity which results in smooth muscle cells' proliferation and migration [ 25].
In addition, we identified and functionally characterized the compounds that provide potent DHPM-dependent Kinhibition inhibition, and were capable of impairing metaphase/anaphase transition together with cell proliferation.
These findings provide evidence that the Q49X mutant is capable of impairing gap-junction distribution and function of key atrial connexins, which might play a role in the predisposition to and onset of AF.
Our findings extend the range of Aβ-containing APP peptides that are capable of impairing synaptic function and suggest that synaptotoxicity can arise from APP processing events in addition to the classical β- and γ-secretase cleavages that produce Aβ.
These results strongly suggested that atorvastatin might be capable of attenuating the impaired spatial learning and memory in AD rat models.
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