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To avoid confounding variables such as endoreduplication, plastomes per cell can also be calculated using methods that do not rely on nuclear DNA.
For the comparison with our study, first, predictions based on expression data only have to be extracted and, subsequently, precision and recall measures need to be calculated using methods similar to those used in our study.
For the third objective, the ICCs, their standard errors and the components of variance [ 36, 37, 42, 43] for the different outcome measures will be calculated using methods that enable adjustment for covariables, together with random effect methods (health-care professionals and PHCT).
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The energy released by each detected signal was calculated using methods introduced by Amitrano et al.54 in a study of cliff collapse in Normandy, France.
Conductance was calculated using methods previously described [6], [8].
Repeat addition processivity (Pi) was calculated using methods similar to those described previously [37], [38].
Estimates of divergence times were calculated using methods based on MCMC Bayesian analyses and non-Bayesian methods.
Sample size was calculated using methods aligned with the World Health Organization STEPS surveys.
The cumulative risk was calculated using methods similar to those described by Peto et al (2000).
The glycemic index of each meal was calculated using methods described previously (21).
The CIs for response rates, TTP and OS were calculated using methods for exact binominal CI (Lentner, 1982).
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