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Vav, another RhoGEF composed of several domains that have been implicated in protein protein interactions in addition to the DH and PH domains, has been shown to be broadly active with several Rho GTPases, such as Rac, RhoA, and Cdc42.
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Similarly, a class of 7-chloro-4-quinolinyl hydrazones was found to be broadly active against a range of Leishmania promastigotes with seven compounds (72) demonstrating EC50 values of <0.5 μg/mL.
The most potent analogue 16l was broadly active against all the tested cancer cell lines (IC50 = 3.16 7.93 μM).
These results suggest that tryptamine and tyramine are broadly active antagonists of insect ORs.
The Hedgehog (Hh) signalling pathway, which is broadly active in early embryonic development, orchestrates tissue patterning in vertebrates and invertebrates.
These concentrations of FeSO4 might be broadly consistent with the concentrations of redox-active iron in lysosomes (although the nature of the redox-active iron and its ligands in lysosomes are unclear).
Chemical and physical parameters were found to be broadly consistent with the experimental data.
Cancer immunotherapy can be broadly divided into "active" and "passive" immunotherapeutic strategies.
In organisms from yeast to humans, H4K16ac is broadly associated with active genes, and the Histone Acetyl Transferase (HAT) that writes the modification is required for viability [ 18- 21].
Faults can be broadly classified into two main areas: active and passive.
Solar still can be broadly classified into two categories, namely, active solar still and passive solar still.
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CEO of Professional Science Editing for Scientists @ prosciediting.com