Different consensus sequences might be bound by tissue-specific isoforms of CstF-RNA binding subunits [ 21] or competitor proteins [ 22].
These regulatory regions are bound by tissue-specific transcription factors (TFs) to control complex gene expression phenotypes (Bradley et al., 2010; ENCODE, 2012; Zinzen et al., 2009).
Brown will not be bound by precedent.
This indicates that these six motifs correlate with promoters that are bound by RNAP in multiple tissues and not tissue specific promoters.
In particular, we assessed the difference in conservation between canonical motifs at Rxrα binding sites that are tissue-specific and sites that are bound by Rxrα in two or more tissues.
In case of the CREB-binding site, it has been shown that the methylated version is bound by C/EBPα whereas the unmethylated version is bound by the CREB protein, resulting in tissue specific gene expression programs.
In mouse nervous tissues, 5-hmC is enriched in actively transcribed genes and is bound by MeCP2 (METHYL-CPG-BINDING PROTEIN 2), a protein that is associated with transcriptional repression when bound to 5-mC (Mellén et al. 2012).
At very low doses, these metals are bound by metallothionein proteins and may be excreted slowly or sequestered in vivo in adipose and other tissues [181, 185].
The upstream neuronal tissue-specific cluster (Exon 1) is associated with a CpG island and is bound by Dali.
