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The purpose of evaluating the regions of disorder within a protein is that such areas are observed to be binding sites for protein-ligand interactions.
Such regions of disorder within proteins are observed to be binding sites for proteins assuming a secondary structure that is observed under x-ray crystallography when in association with the partner ligand [23], [24].
Motifs found in the 5' region are expected to be binding sites for transcription factors or other DNA binding proteins that affect transcription, while motifs in the 3' UTR are expected to be sites for regulation of mRNA by microRNAs or RNA binding proteins.
Lys158 and Phe300 may also be binding sites for Asc as described below.
These sequences have been shown to be binding sites for a bidirectional transcription termination factor, DmTTF (Roberti et al. 2003).
Among these, the −50GC and −110GC boxes appear highly relevant as they seem to be binding sites for ABCB1 activators and repressors.
Similar(47)
Here, we demonstrate a method to engineer highly selective synthetic antibodies (sABs) against LD2 and LD4 that are binding sites for focal adhesion kinase (FAK) and other proteins.
This 2 kb region contains 237 bases covered by potential TFBS, many of which were binding sites for Sp1.
For the case of a transcriptional activator, there are binding sites for the transcription factors upstream of the regulated gene, and when these sites are occupied transcription proceeds at some rate, but when the site is empty transcription is inhibited.
Post-transcriptional regulation requires a signal on the target mRNA, usually in the form of sequence or structural motifs present in the UTRs that are binding sites for a trans-acting factor.
HSEs are binding sites for HSFs (heat-shock factors, Figure 1), transcription factors whose trimerization mediates the heat-shock response in eukaryotes [11], [12] in combination with numerous co-regulators [13].
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