For example, Hall and coworkers demonstrated in this way that the C-termini of GPCR proteins such as P2Y1R, mGluR5, and β1AR are binding partners for several PDZ domains [ 28- 30].
It remains to be determined whether there are binding partners for HOIL-1 other than HOIP and SHARPIN, and, if so, whether this results in HOIL-1-mediated generation of linear or other ubiquitin chain linkages.
Thus, when two proteins significantly co-occur in a large number of genomes or can be observed as fusion proteins in a subset of genomes, they are likely to be binding partners or enzymes needed for a specific metabolic pathway.
There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound.
Given the close proximity of CAHM to QKI, we speculate that CAHM transcripts might also be RNA binding partners for the Qki protein and may perhaps be involved in directing its specificity.
Therefore it seems unlikely that the major platelet glycoproteins, such as integrin αIIbβ3 (80000 copies) [ 35] or GPIb-IX-V (25000 copies) [ 36], would be direct binding partners for Tspan9.
Free BPA has also been shown to bind TR and the androgen receptors (Lee et al. 2003; Matsushima et al. 2007; Moriyama et al. 2002), which may play roles in adipogenesis and could be potential binding partners for BPA-G, warranting further study.
The representation of GDs in these HT data sets is relatively low (3%), which means that much work is needed to distinguish which of the protein hits from the HT experiments are phosphoproteins that bind directly to 14-3-3 14-3-3 14-3-3e indirect binding pandners for 14-3-3.
This analysis enabled us to predict that a further two glycans (14 and 21), which are found conjugated solely by Sp14, are probable binding partners for JAA-F11.
