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Modifying native organism through evolutionary engineering for desirable purpose often provides great breakthroughs to challenging obstacles in areas within biotechnology including biofuel production, screening of desirable phenotypes, etc. Conventional mutation methods, however, can be biased to certain types of mutations which restrict the accessibility to desirable phenotypes.
Although comprehensive, there is a possibility that both DBTSS and GEO data might be biased to certain biological niches.
On the other, biochemical knowledge can be biased to certain pathways and processes that have been more intensely studied than others.
If retrotransposition of L1s is linked to their noncanonical replication, L1 insertions are anticipated to be biased to certain sets of L1-rich EtoL domains, the early replication and transcriptional competence of which is characteristic of either embryonic or cancer cells.
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GO analysis revealed that DEGs between any two stages were biased to certain functional classifications.
This approach prevented the negative set from being biased to certain regions of the genome.
To further investigate whether these genes with expression divergence between two alternatively spliced models are biased to certain functions, we submitted these genes for GSEA.
Even if the transposable elements are biased to certain parts of the genome, the differences in the local mutation rate are relatively minor.
Taxon sampling has been biased to certain orders including Harpacticoida: Tigriopus japonicus [ 18, 19], Tigriopus californicus [ 14]; Siphonostomatoida: Lepeophtheirus salmonis [ 20] and Cyclopoida: Paracyclopina nana [ 21].
Compared with the gDNA heavy chain libraries, the corresponding cDNA heavy chain libraries had significantly higher percentages of clones using IGHV1 and IGHV3 lineages (Fig. 1), and were biased to certain VH1 and VH3 subfamilies, including IGHV1 18, 1 2 and 1 69, and IGHV 3 11, 3 21, 3 23, 3 30, 3 33, 3 49, 3 7 and 3 74 (Fig. 2).
In further studies we want to obtain a set of different scoring functions that are biased to a certain target class and can be used for docking and scoring within ParaDockS.
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