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We systematically reviewed estimates of overdetection to assess the extent to which these might be biased by study methods.
However, as this model is not based on the comparisons between the index tests, but on the pooling of results for each test across all available studies, the results may be biased by study characteristics.
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Whilst this number may be biased by studies focused only on protein-coding genes, exome sequencing has nevertheless become a standard tool in the search for the cause of monogenic disorders in humans [ 3– 7].
More recently, we and others have evaluated the impact of design in medical and surgical research, and concluded that the mean gain comparing new therapies to established therapies was biased by study design in nonrandomized trials (Colditz et al., 1989; Miller et al., 1989).
The low prevalence of GOR-CC in the present study might be biased by the studied population in a university hospital, but may reflect low prevalence of GOR in the general population in Japan where 21 to 27% of the general population are overweight (BMI ≧ 25 kg/m) [ 10] and endoscopically diagnosed and/or symptomatic GOR is reported to be 16% and 18% in population based studies [ 11, 12].
A coherent picture emerged across the individual interviews and group interviews, but our findings may be biased by the small study sample and lack of independent data.
In addition, with almost complete follow-up, the results are unlikely to be biased by selection of study participants or loss to follow up.
Our results may be biased by our omission of unpublished studies, studies published in other languages and studies published in journals not indexed in the databases we searched.
Meta-analyses of medication safety effects without stratification by dose could be biased by the inclusion of studies where dosages differ substantially across studies [ 4].
Determining the extent to which comments may be biased by negative comments requires further study.
Therefore, reported PPE use in this study may be biased by inaccurate recall or a tendency to report behavior that HCWs know is recommended.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com